DC: Martin Skrtel
An experienced player who will be key for Liverpool in this big game, Martin Skrtel is almost a guaranteed starter every week for the Reds.
DC: Mamadou Sakho
With Dejan Lovren so poor against West Ham, Mamadou Sakho could come in alongside Skrtel in defence for this crucial fixture.
DM: Lucas Leiva
Despite nearly leaving Anfield in the summer, Lucas Leiva now looks to have a key role to play for this Liverpool side in the defensive midfield role.
MC: Emre Can
Another defensive-minded player, Emre Can could come in for Liverpool to help defend against United’s skillful attackers like Juan Mata and Memphis Depay.
MC: Jordan Henderson
Liverpool’s captain and midfield general, Jordan Henderson will have to be at his best in the midfield battle against the likes of Morgan Schneiderlin.